User profiles for Willy Roque
 | Willy Roque BarbozaUniversity of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 323 |
Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
…, H Shaghaghi, DL Schriner, W Roque… - … of Physiology-Lung …, 2019 - journals.physiology.org
Cellular senescence is a biological process by which cells lose their capacity to proliferate
yet remain metabolically active. Although originally considered a protective mechanism to …
yet remain metabolically active. Although originally considered a protective mechanism to …
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease of unknown
etiology with limited treatment options. It is characterized by repetitive injury to alveolar …
etiology with limited treatment options. It is characterized by repetitive injury to alveolar …
[HTML][HTML] Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
Background Adipose tissue accumulation in specific body compartments has been associated
with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct …
with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct …
[HTML][HTML] Mitochondrial quality control in age-related pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown
etiology. About 100,000 people in the US have IPF, with a 3-year median life expectancy post-…
etiology. About 100,000 people in the US have IPF, with a 3-year median life expectancy post-…
[HTML][HTML] MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease
The pathogenesis of chronic obstructive pulmonary disease (COPD) involves aberrant
responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not all …
responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not all …
[HTML][HTML] A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis
W Roque, A Boni, J Martinez-Manzano… - International Journal of …, 2020 - mdpi.com
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the activation
of fibroblasts and the irreversible deposition of connective tissue matrices that leads to …
of fibroblasts and the irreversible deposition of connective tissue matrices that leads to …
Matched cohort study of convalescent COVID-19 plasma treatment in severely or life threateningly ill COVID-19 patients
…, JP Zertuche, M McKenna, W Roque… - Open Forum …, 2021 - academic.oup.com
Background The utility of convalescent coronavirus disease 2019 (COVID-19) plasma (CCP)
in the current pandemic is not well defined. We sought to evaluate the safety and efficacy of …
in the current pandemic is not well defined. We sought to evaluate the safety and efficacy of …
Heat shock proteins in pulmonary fibrosis: Pawns of cell homeostasis
W Roque - American Journal of Physiology-Cell Physiology, 2022 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that primarily affects the elderly. Up to
date, the specific pathogenesis of IPF remains unknown. However, it is theorized to be caused …
date, the specific pathogenesis of IPF remains unknown. However, it is theorized to be caused …
[HTML][HTML] A model of the aged lung epithelium in idiopathic pulmonary fibrosis
…, K Cuevas-Mora, R Para, C Tran, W Roque… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor
prognosis and is thought to arise from repetitive micro injuries to the alveolar epithelium. To …
prognosis and is thought to arise from repetitive micro injuries to the alveolar epithelium. To …
Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism
…, MA Planchart Ferretto, W Roque… - Expert Review of …, 2023 - Taylor & Francis
Background Given the heterogeneity of predisposing factors associated with pulmonary
infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary …
infarction (PI) and the lack of clinically relevant outcomes among patients with acute pulmonary …