Converging evidence from genetic, pathological and experimental studies have
increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). …

… Research of Wilma DJ van de Berg is funded by Stichting Parkinson Fonds, Internationale
… Wilma DJ van de Berg reports the following disclosures: contract research and consultancy …

Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …

Parkinson's disease (PD) is characterized by a gradual accumulation of neuropathology that
may begin many years before a clinical diagnosis can be made using currently accepted …

Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the
substantia nigra (SN) of Parkinson’s disease (PD) patients. Little is known, however, about …

Background Despite decades of intensive research, to date, there is no accepted diagnosis
for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, …

To gain a better understanding of the significance of α‐synuclein pathological conditions
during disease progression in Parkinson's disease, we investigated whether 1) nigral neuronal …

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including
C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn—…

… Simone van den Berge was involved in the conception and design, collection and assembly
of … Wilma van de Berg was involved in provision of study material, collection of data, data …

α-Synuclein (α-syn), a small protein that has the intrinsic propensity to aggregate, is implicated
in several neurodegenerative diseases including Parkinson’s disease (PD), dementia …