Accessible chromatin is important for RNA polymerase II recruitment and transcription initiation
at eukaryotic promoters. We investigated the mechanistic links between promoter DNA …

Transcription, the process of copying genetic information from DNA to messenger RNA, is
regulated by sequence-specific DNA-binding proteins known as transcription factors (TFs). …

Many transcription factors (TFs) localize in nuclear clusters of locally increased concentrations,
but how TF clustering is regulated and how it influences gene expression is not well …

An important distinction is frequently made between constitutively expressed housekeeping
genes versus regulated genes. Although generally characterized by different DNA elements, …

Transcription factors are important regulators of cell fate and function. Knowledge about where
transcription factors are bound in the genome is crucial for understanding their function. A …

Protein– DNA interactions are dynamic, and these dynamics are an important aspect of
chromatin‐associated processes such as transcription or replication. Due to a lack of methods to …

Studies in neuroscience and immunology have clarified much of the anatomical and cellular
basis for bidirectional interactions between the nervous and immune systems. As with other …

Chromatin immunoprecipitation (ChIP) is a commonly used technique to investigate which
parts of a genome are bound by a particular protein. The result of ChIP is often interpreted in …

Background: In patients with early rheumatoid arthritis, initial combination therapies provide
earlier clinical improvement and less progression of joint damage after 1 year compared …

The literature on chronic diseases recognizes the role of illness cognition as a mediator
between stress and illness. Few conceptualizations and instruments, however, give an …