User profiles for Wing-Pui Kong

Wing Pui Kong

NIH
Verified email at mail.nih.gov
Cited by 17467

[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

…, D Garcia-Dominguez, LZ Ma, I Renzi, WP Kong… - Nature, 2020 - nature.com
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …

[HTML][HTML] Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

…, G Stewart-Jones, S Himansu, WP Kong… - … England Journal of …, 2020 - Mass Medical Soc
Background Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed.
The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on …

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

…, L Wang, W Shi, WP Kong… - Proceedings of the …, 2017 - National Acad Sciences
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus
that since its emergence in 2012 has caused outbreaks in human populations with case-…

p53 inhibition by the LANA protein of KSHV protects against cell death

J Friborg Jr, W Kong, MO Hottiger, GJ Nabel - Nature, 1999 - nature.com
Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, has been
implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative …

[HTML][HTML] A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

Z Yang, W Kong, Y Huang, A Roberts, BR Murphy… - Nature, 2004 - nature.com
Public health measures have successfully identified and contained outbreaks of the severe
acute respiratory syndrome (SARS) coronavirus (SARS-CoV) 1 , 2 , 3 , 4 , 5 , but concerns …

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

…, JC Boyington, JRR Whittle, SS Rao, WP Kong… - Nature, 2013 - nature.com
Influenza viruses pose a significant threat to the public and are a burden on global health
systems 1 , 2 . Each year, influenza vaccines must be rapidly produced to match circulating …

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

…, PM McTamney, CJ Wei, M Kanekiyo, WP Kong… - Nature medicine, 2015 - nature.com
The antibody response to influenza is primarily focused on the head region of the hemagglutinin
(HA) glycoprotein, which in turn undergoes antigenic drift, thus necessitating annual …

pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN

…, Y Huang, L Ganesh, K Leung, WP Kong… - Journal of …, 2004 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus (SARS-CoV) synthesizes several putative
viral envelope proteins, including the spike (S), membrane (M), and small envelope (E) …

[HTML][HTML] A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

…, H Andersen, S Sun, HA Holdaway, WP Kong… - Nature medicine, 2010 - nature.com
Chikungunya virus (CHIKV) has infected millions of people in Africa, Europe and Asia 1 , 2
since this alphavirus reemerged from Kenya in 2004. The severity of the disease and the …

Induction of broadly neutralizing H1N1 influenza antibodies by vaccination

CJ Wei, JC Boyington, PM McTamney, WP Kong… - Science, 2010 - science.org
The rapid dissemination of the 2009 pandemic influenza virus underscores the need for
universal influenza vaccines that elicit protective immunity to diverse viral strains. Here, we show …