User profiles for Wolfgang Brehm
Wolfgang BrehmSoftware Engineer at Karl Storz Verified email at desy.de Cited by 1399 |
From lithium‐ion to sodium‐ion batteries: advantages, challenges, and surprises
Mobile and stationary energy storage by rechargeable batteries is a topic of broad societal
and economical relevance. Lithium‐ion battery (LIB) technology is at the forefront of the …
and economical relevance. Lithium‐ion battery (LIB) technology is at the forefront of the …
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
[HTML][HTML] Recent developments in CrystFEL
CrystFEL is a suite of programs for processing data from `serial crystallography' experiments,
which are usually performed using X-ray free-electron lasers (FELs) but also increasingly …
which are usually performed using X-ray free-electron lasers (FELs) but also increasingly …
[HTML][HTML] Megahertz serial crystallography
The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …
Structural basis of ligand recognition at the human MT1 melatonin receptor
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian
rhythms 1 by synchronization to environmental cues and is involved in diverse physiological …
rhythms 1 by synchronization to environmental cues and is involved in diverse physiological …
Breaking the indexing ambiguity in serial crystallography
W Brehm, K Diederichs - Acta Crystallographica Section D: Biological …, 2014 - scripts.iucr.org
In serial crystallography, a very incomplete partial data set is obtained from each diffraction
experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which …
experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which …
[HTML][HTML] XGANDALF–extended gradient descent algorithm for lattice finding
Serial crystallography records still diffraction patterns from single, randomly oriented crystals,
then merges data from hundreds or thousands of them to form a complete data set. To …
then merges data from hundreds or thousands of them to form a complete data set. To …
[HTML][HTML] Serial protein crystallography in an electron microscope
Serial X-ray crystallography at free-electron lasers allows to solve biomolecular structures
from sub-micron-sized crystals. However, beam time at these facilities is scarce, and involved …
from sub-micron-sized crystals. However, beam time at these facilities is scarce, and involved …
[HTML][HTML] Identification of rogue datasets in serial crystallography
G Assmann, W Brehm, K Diederichs - Journal of applied …, 2016 - scripts.iucr.org
Advances in beamline optics, detectors and X-ray sources allow new techniques of
crystallographic data collection. In serial crystallography, a large number of partial datasets from …
crystallographic data collection. In serial crystallography, a large number of partial datasets from …
[HTML][HTML] Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2.
Initially reported to target the viral main protease (M pro ), its moderate activity in M …
Initially reported to target the viral main protease (M pro ), its moderate activity in M …