User profiles for Wolfgang Brehm

Wolfgang Brehm

Software Engineer at Karl Storz
Verified email at desy.de
Cited by 1399

From lithium‐ion to sodium‐ion batteries: advantages, challenges, and surprises

PK Nayak, L Yang, W Brehm… - Angewandte Chemie …, 2018 - Wiley Online Library
Mobile and stationary energy storage by rechargeable batteries is a topic of broad societal
and economical relevance. Lithium‐ion battery (LIB) technology is at the forefront of the …

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

…, K Lorenzen, B Krichel, JD Kopicki, L Gelisio, W Brehm… - Science, 2021 - science.org
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human
suffering. To date, no effective drug is available to directly treat the disease. In a search for …

[HTML][HTML] Recent developments in CrystFEL

TA White, V Mariani, W Brehm, O Yefanov… - Journal of applied …, 2016 - scripts.iucr.org
CrystFEL is a suite of programs for processing data from `serial crystallography' experiments,
which are usually performed using X-ray free-electron lasers (FELs) but also increasingly …

[HTML][HTML] Megahertz serial crystallography

…, J Bielecki, S Botha, D Boukhelef, W Brehm… - Nature …, 2018 - nature.com
The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …

Structural basis of ligand recognition at the human MT1 melatonin receptor

…, C Gati, A Batyuk, ST Slocum, A Ishchenko, W Brehm… - Nature, 2019 - nature.com
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian
rhythms 1 by synchronization to environmental cues and is involved in diverse physiological …

Breaking the indexing ambiguity in serial crystallography

W Brehm, K Diederichs - Acta Crystallographica Section D: Biological …, 2014 - scripts.iucr.org
In serial crystallography, a very incomplete partial data set is obtained from each diffraction
experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which …

[HTML][HTML] XGANDALF–extended gradient descent algorithm for lattice finding

…, A Barty, TA White, V Mariani, W Brehm… - … A: Foundations and …, 2019 - scripts.iucr.org
Serial crystallography records still diffraction patterns from single, randomly oriented crystals,
then merges data from hundreds or thousands of them to form a complete data set. To …

[HTML][HTML] Serial protein crystallography in an electron microscope

…, EC Schulz, LA Bultema, Y Gevorkov, W Brehm… - Nature …, 2020 - nature.com
Serial X-ray crystallography at free-electron lasers allows to solve biomolecular structures
from sub-micron-sized crystals. However, beam time at these facilities is scarce, and involved …

[HTML][HTML] Identification of rogue datasets in serial crystallography

G Assmann, W Brehm, K Diederichs - Journal of applied …, 2016 - scripts.iucr.org
Advances in beamline optics, detectors and X-ray sources allow new techniques of
crystallographic data collection. In serial crystallography, a large number of partial datasets from …

[HTML][HTML] Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

…, R Cox, HN Chapman, C Betzel, W Brehm… - Communications …, 2023 - nature.com
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2.
Initially reported to target the viral main protease (M pro ), its moderate activity in M …