The development of concepts describing potassium clearance mechanisms in the mammalian
central nervous system in the last 35 years is reviewed. The pattern of excess potassium …

The last few years have seen a rapid expansion in our knowledge of glial cell properties and
this is especially true of involvement of glial cells in ion regulation. However, our conceptual …

Lactate released into the surrounding salt solution as well as the cellular lactate content
were measured in cerebral primary cultures of mouse astrocytes and of mouse neurons. Any …

In order to establish the relative distribution of a GFAP-negative population of astrocytes, and
its change in gliotic tissue, sections of the stratum radiatum of the CA1 hippocampal layer …

Extracellular [K + ] can range within 2.5–3.5 mM under normal conditions to 50–80 mM under
ischemic and spreading depression events. Sustained exposure to elevated [K + ] o has …

Since 1992, it has been possible to record ionic currents from identified astrocytes in situ,
using brain slice technology. Brain slice recordings confirm previous in vitro findings that …

Acute brain injuries evoke various response cascades directing the formation of the glial
scar. Here, we report that acute lesions associated with hemorrhagic injuries trigger a re-…

It has long been recognized that potassium ions are released from brain tissue during
excitation (Cicardo and Torino, 1942) and also that the extracellular potassium concentration …

Intracellular lactate content and release of lactate into the surrounding medium of mouse
astrocytes in primary culture was measured using the lactate dehydrogenase method. During …

Potassium accumulation and water transport into mouse astrocytes in primary cultures were
investigated when external potassium was increased from 3 to 12 mM. The intracellular …