Current efforts aim to functionally characterize each gene in model plants. Frequently, however,
no morphological or biochemical phenotype can be ascribed for antisense or knock-out …

Motivation: Metabolite profiling aims at an unbiased identification and quantification of all the
metabolites present in a biological sample. Based on their pair-wise correlations, the data …

Arabidopsis thaliana serves as a model organism for the study of fundamental physiological,
cellular, and molecular processes. It has also greatly advanced our understanding of …

The primary aim of “omic” technologies is the nontargeted identification of all gene products
(transcripts, proteins, and metabolites) present in a specific biological sample. By their nature…

The epigenome orchestrates genome accessibility, functionality, and three-dimensional
structure. Because epigenetic variation can impact transcription and thus phenotypes, it may …

A novel extraction protocol is described with which metabolites, proteins and RNA are
sequentially extracted from the same sample, thereby providing a convenient procedure for the …

The aggregation of hypertrophic macrophages constitutes the basis of all granulomatous
diseases, such as tuberculosis or sarcoidosis, and is decisive for disease pathogenesis. …

Tumor cells may adapt to metabolic challenges by alternating between glycolysis and oxidative
phosphorylation (OXPHOS). To target this metabolic plasticity, we combined intermittent …

10.7554/eLife.05828.001 Metabolic adjustment to changing environmental conditions,
particularly balancing of growth and defense responses, is crucial for all organisms to survive. …

Metabolomics, in particular gas chromatography–mass spectrometry (GC–MS) based metabolite
profiling of biological extracts, is rapidly becoming one of the cornerstones of functional …