Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …

Hypertension is a leading cause of global disease, mortality, and disability. While individuals
of African descent suffer a disproportionate burden of hypertension and its complications, …

Introduction Lymphangioleiomyomatosis (LAM) occurs either associated with tuberous
sclerosis complex (TSC) or as sporadic disease (S-LAM). Risk factors for development of S-LAM …

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this ‘missing heritability’. We …

Despite the many successes of genome-wide association studies (GWAS), the known
susceptibility variants identified by GWAS have modest effect sizes, leading to notable skepticism …

Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …

Prenatal exposure to persistent organic pollutants (POPs) has been linked to numerous
adverse birth outcomes among newborn infants in many epidemiological studies. Although …

Genome-wide association studies have identified thousands of single nucleotide variants
and small indels that contribute to variation in hematologic traits. While structural variants are …

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic
obstructive pulmonary disease (COPD), predictive performance is limited when the discovery …

Background Many disease phenotypes are outcomes of the complicated interplay between
multiple genes, and multiple phenotypes are affected by a single or multiple genotypes. …