User profiles for Wouter Wiegant
 | Wouter W WiegantResearch Technician at The Haico van Attikum Research group, LUMC, the Netherlands Verified email at lumc.nl Cited by 3624 |
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J
…, BC Godthelp, Y Vries, S Hussain, WW Wiegant… - Nature …, 2005 - nature.com
The protein predicted to be defective in individuals with Fanconi anemia complementation
group J (FA-J), FANCJ, is a missing component in the Fanconi anemia pathway of genome …
group J (FA-J), FANCJ, is a missing component in the Fanconi anemia pathway of genome …
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection
…, E Martini, B Khadaroo, K Dubois, WW Wiegant… - Nature, 2012 - nature.com
Several homology-dependent pathways can repair potentially lethal DNA double-strand
breaks (DSBs). The first step common to all homologous recombination reactions is the 5′–3′ …
breaks (DSBs). The first step common to all homologous recombination reactions is the 5′–3′ …
[HTML][HTML] A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
…, NS Verkaik, T Turul, WW Wiegant… - The Journal of …, 2009 - Am Soc Clin Investig
Radiosensitive T – B – severe combined immunodeficiency (RS-SCID) is caused by defects
in the nonhomologous end-joining (NHEJ) DNA repair pathway, which results in failure of …
in the nonhomologous end-joining (NHEJ) DNA repair pathway, which results in failure of …
[PDF][PDF] PARP1 links CHD2-mediated chromatin expansion and H3. 3 deposition to DNA repair by non-homologous end-joining
MS Luijsterburg, I de Krijger, WW Wiegant, RG Shah… - Molecular cell, 2016 - cell.com
The response to DNA double-strand breaks (DSBs) requires alterations in chromatin
structure to promote the assembly of repair complexes on broken chromosomes. Non-homologous …
structure to promote the assembly of repair complexes on broken chromosomes. Non-homologous …
[PDF][PDF] Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality
E Gogola, AA Duarte, JR de Ruiter, WW Wiegant… - Cancer cell, 2018 - cell.com
Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for
the treatment of homologous recombination (HR)-deficient cancers. Despite the success of …
the treatment of homologous recombination (HR)-deficient cancers. Despite the success of …
The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage
G Smeenk, WW Wiegant, H Vrolijk, AP Solari… - Journal of Cell …, 2010 - rupress.org
Cells respond to ionizing radiation (IR)–induced DNA double-strand breaks (DSBs) by
orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal and …
orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal and …
[HTML][HTML] A new type of radiosensitive T–B–NK+ severe combined immunodeficiency caused by a LIG4 mutation
…, NS Verkaik, WW Wiegant… - The Journal of …, 2006 - Am Soc Clin Investig
V(D)J recombination of Ig and TCR loci is a stepwise process during which site-specific
DNA double-strand breaks (DSBs) are made by RAG1/RAG2, followed by DSB repair by …
DNA double-strand breaks (DSBs) are made by RAG1/RAG2, followed by DSB repair by …
Poly (ADP-ribosyl) ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling
G Smeenk, WW Wiegant, JA Marteijn… - Journal of cell …, 2013 - journals.biologists.com
Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) arising in native chromatin
elicit an RNF8/RNF168-dependent ubiquitylation response, which triggers the recruitment …
elicit an RNF8/RNF168-dependent ubiquitylation response, which triggers the recruitment …
[PDF][PDF] ZMYND8 co-localizes with NuRD on target genes and regulates poly (ADP-ribose)-dependent recruitment of GATAD2A/NuRD to sites of DNA damage
…, RR Edupuganti, MP Baltissen, WW Wiegant… - Cell reports, 2016 - cell.com
NuRD (nucleosome remodeling and histone deacetylase) is a versatile multi-protein complex
with roles in transcription regulation and the DNA damage response. Here, we show that …
with roles in transcription regulation and the DNA damage response. Here, we show that …
A new non‐catalytic role for ubiquitin ligase RNF8 in unfolding higher‐order chromatin structure
…, K Acs, L Ackermann, WW Wiegant… - The EMBO …, 2012 - embopress.org
The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the
ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we …
ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we …