Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

Trans-homolog interactions have been studied extensively in Drosophila, where homologs
are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure …

Genome organization involves cis and trans chromosomal interactions, both implicated in
gene regulation, development, and disease. Here, we focus on trans interactions in Drosophila…

This study explores the relationship between three-dimensional genome organization and
ultraconserved elements (UCEs), an enigmatic set of DNA elements that are perfectly …

Protein conformations are shaped by cellular environments, but how environmental
changes alter the conformational landscapes of specific proteins in vivo remains largely …

The development of the human brain and nervous system can be affected by genetic or
environmental factors. Here we focus on characterizing the genetic perturbations that …

… Christina Stephen’s strength, determination, and baking (best tres leches cake to date!),
Wren Saylor’s imagination, love, and understanding, Elissa Fink’s coffee walks with Ella and her …

… I also want to thank to Leo Gendelev, Garrett Gaskins, and Wren Saylor. Thanks also to a
small army for animal husbandry and protocol development, including Louie Ramos, Julian …

Functional cells and tissues differentiated from human pluripotent stem cells (hPSCs) have
potential applications for disease modeling, drug discovery and regenerative therapy. …

… Hooke thought that this would be easy to prove whereupon Wren offered Hooke 40 shillings
if he could produce the proof within 2 weeks. The 2 weeks passed and nothing more was …