The phenazines include upward of 50 pigmented, heterocyclic nitrogen-containing secondary
metabolites synthesized by some strains of fluorescent Pseudomonas spp. and a few …

Phenazines are natural products which are produced by bacteria or by archaeal
Methanosarcina species. The tricyclic ring system enables redox processes, which producing …

Physicians of the 19th century were familiar with the conspicuous occurrence of “blue pus”,
which they sometimes observed in patients with severe purulent wounds. Even older are …

In the course of Legionnaires’ disease, the bacterium Legionella pneumophila affects the
intracellular vesicular trafficking of infected eukaryotic cells by recruiting the small guanosine …

Phenazines are versatile secondary metabolites of bacterial origin that function in biological
control of plant pathogens and contribute to the ecological fitness and pathogenicity of the …

The synthesis of deoxy-thymidine di-phosphate (dTDP)–L-rhamnose, an important component
of the cell wall of many microorganisms, is a target for therapeutic intervention. The first …

Protein prenylation is a widespread phenomenon in eukaryotic cells that affects many
important signaling molecules. We describe the structure-guided design of engineered protein …

Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that
need to be disrupted for membrane attachment and targeting of Rab proteins. The …

Brd4 is a member of the bromodomains and extra terminal domain (BET) family of proteins
that recognize acetylated chromatin structures through their bromodomains and act as …

Phenazine compounds represent a large class of bacterial metabolites that are produced by
some fluorescent Pseudomonas spp. and a few other bacterial genera. Phenazines were …