Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense
RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped …

Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae
family with an 11 kb positive strand RNA genome that folds to enable virus function. Here, …

Host defenses against viral infections depend on a complex interplay of innate (nonspecific)
and adaptive (specific) components. In the early stages of infection, innate mechanisms …

It is well established that influenza A virus (IAV) attachment to and infection of epithelial
cells is dependent on sialic acid (SIA) at the cell surface, although the specific receptors that …

The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify
specific transmembrane glycoproteins that function as bone fide entry receptors for influenza A …

Specific protein receptors that mediate internalization and entry of influenza A virus (IAV) have
not been identified for any cell type. Sialic acid (SIA), the primary attachment factor for IAV …

Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development
of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties …

Background Despite the availability of specific vaccines and antiviral drugs, influenza continues
to impose a heavy toll on human health worldwide. Passive transfer of specific antibody (…

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune
responses to influenza virus. To do this, respiratory DCs must ferry viral antigen from the lung to …

The molecular basis of dengue virus (DENV) attenuation remains ambiguous and hampers
a targeted approach to derive safe but nonetheless immunogenic live vaccine candidates. …