Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes;
the ensemble of these binding events forms a regulatory network, constituting the wiring …

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

Genomic structural variants (SVs) are abundant in humans, differing from other forms of
variation in extent, origin and functional impact. Despite progress in SV characterization, the …

Large-scale genomic characterization of tumors from prospective cohort studies may yield
new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 …

Open source and open data have been driving forces in bioinformatics in the past. However,
privacy concerns may soon change the landscape, limiting future access to important data …

We report on molecular analyses of baseline tumor samples from the phase 3 JAVELIN
Renal 101 trial (n = 886; NCT02684006 ), which demonstrated significantly prolonged …

… Xinmeng Jasmine Mu … Mu XJ, Lu ZJ, Kong Y, Lam HYK, Gerstein MB: Analysis of
genomic variation in non-coding elements using population-scale sequencing data from the …

Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in noncoding …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

Identification of noncoding drivers from thousands of somatic alterations in a typical tumor is
a difficult and unsolved problem. We report a computational framework, FunSeq2, to …