We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of
Acinetobacter baumannii and established that the bacterial capsule is the receptor for these …

Background Clinical phage therapy is often delivered alongside antibiotics. However, the
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we assessed …

The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade
the human immune system, which is associated with reduced levels of neutrophil recruitment. …

Acinetobacter baumannii is a Gram negative opportunistic pathogen that has demonstrated
a significant insurgence in the prevalence of infections over recent decades. With only a …

Background. Acinetobacter baumannii is one of the most notorious hospital-acquired
pathogens, and novel treatment strategies are desperately required. Two-component regulatory …

Innate cellular immune responses are a critical first-line defense against invading bacterial
pathogens. Leukocyte migration from the bloodstream to a site of infection is mediated by …

The genetic mechanisms that contribute to reduced susceptibility to vancomycin in
Staphylococcus aureus are complex and heterogeneous. In addition, debate is emerging as to the …

The occurrence of mutations in methicillin-resistant Staphylococcus aureus (MRSA) during
persistent infection leads to antimicrobial resistance but may also impact host-pathogen …

Staphylococcus aureus is a notorious human bacterial pathogen with considerable capacity
to develop antibiotic resistance. We have observed that human infections caused by highly …

Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic
and persistent infections despite active antibiotic treatment. The molecular basis for this …