Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as
molecular recognition elements (MoREs). They fold into ordered structures upon binding to …

Histone chaperones facilitate assembly and disassembly of nucleosomes. Understanding
the process of how histone chaperones associate and dissociate from the histones can help …

The organized three-dimensional chromosome architecture in the cell nucleus provides
scaffolding for precise regulation of gene expression. When the cell changes its identity in the …

Biomolecular function is realized by recognition, and increasing evidence shows that recognition
is determined not only by structure but also by flexibility and dynamics. We explored a …

The energy landscape approach has played a fundamental role in advancing our understanding
of protein folding. Here, we quantify protein folding energy landscapes by exploring the …

Biomolecular functions are determined by their interactions with other molecules. Biomolecular
recognition is often flexible and associated with large conformational changes involving …

Protein-DNA recognition is a central biological process that governs the life of cells. A protein
will often undergo a conformational transition to form the functional complex with its target …

Calmodulin (CaM) is found to have the capability to bind multiple targets. Investigations on
the association mechanism of CaM to its targets are crucial for understanding protein–protein …

We developed a nonequilibrium model to study chromosome structural reorganizations within
a simplified cell developmental system. From the chromosome structural perspective, we …

Allosteric regulation plays a fundamental role in innumerable biological processes.
Understanding its dynamic mechanism and impact at the molecular level is of great importance in …