Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers
host immune responses such as the production of type I interferons. Cytosolic DNA induces …
host immune responses such as the production of type I interferons. Cytosolic DNA induces …
[HTML][HTML] Pyroptosis: mechanisms and diseases
…, X Zhang, N Liu, L Tang, C Peng, X Chen - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …
innate immunity and disease. The research scope of pyroptosis has expanded with the …
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial
defense but can also result in autoimmunity. This DNA signaling pathway requires the …
defense but can also result in autoimmunity. This DNA signaling pathway requires the …
Fluoroethylene carbonate additives to render uniform Li deposits in lithium metal batteries
Lithium (Li) metal has been considered as an important substitute for the graphite anode to
further boost the energy density of Li‐ion batteries. However, Li dendrite growth during Li …
further boost the energy density of Li‐ion batteries. However, Li dendrite growth during Li …
[HTML][HTML] Association of inflammatory markers with the severity of COVID-19: A meta-analysis
Objectives Studies reported associations of inflammatory markers with the severity of COVID-19,
but conclusions were inconsistent. We aimed to provide an overview of the association …
but conclusions were inconsistent. We aimed to provide an overview of the association …
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
Because undesirable pharmacokinetics and toxicity of candidate compounds are the main
reasons for the failure of drug development, it has been widely recognized that absorption, …
reasons for the failure of drug development, it has been widely recognized that absorption, …
[HTML][HTML] The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
INTRODUCTION Sensing of pathogenic microbes and tissue damage by the innate immune
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA, …
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA, …
[HTML][HTML] Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …
The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton
T Leung, XQ Chen, E Manser, L Lim - Molecular and cellular …, 1996 - Am Soc Microbiol
The GTPase RhoA has been implicated in various cellular activities, including the formation
of stress fibers, motility, and cytokinesis. We recently reported on a p150 serine/threonine …
of stress fibers, motility, and cytokinesis. We recently reported on a p150 serine/threonine …