Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is
thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) …

The molecular basis for breast cancer metastasis to the brain is largely unknown 1 , 2 . Brain
relapse typically occurs years after the removal of a breast tumour 2 , 3 , 4 , suggesting that …

Cells released from primary tumors seed metastases to specific organs by a nonrandom
process, implying the involvement of biologically selective mechanisms. Based on clinical, …

How organ-specific metastatic traits arise in primary tumors remains unknown. Here, we show
a role of the breast tumor stroma in selecting cancer cells that are primed for metastasis in …

Recent studies by our group and others demonstrated a required and conserved role of Stim
in store-operated Ca 2+ influx and Ca 2+ release-activated Ca 2+ (CRAC) channel activity. …

A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β
pathway, yet, paradoxically, they are characterized by elevated TGF-β production. Here, we …

Metastasis may arise years after removal of a primary tumor. The mechanisms allowing
latent disseminated cancer cells to survive are unknown. We report that a gene expression …

Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the
brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as a …

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase
metastasis 1 , 2 . This paradox may be resolved by vessel normalization 3 , which involves …

Background Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant
breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive …