The substrates of most protein kinases remain unknown because of the difficulty tracing
signaling pathways and identifying sites of protein phosphorylation. Here we describe a method …

Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling pathways
driving cell proliferation and survival have been difficult to identify, in part because of the …

Stimulating presynaptic terminals can increase the proton concentration in synapses.
Potential receptors for protons are acid-sensing ion channels (ASICs), Na + - and Ca 2+ -…

Extracellular proton concentrations in the brain may be an important signal for neuron function.
Proton concentrations change both acutely when synaptic vesicles release their acidic …

BACKGROUND: The molecular mechanisms underlying innate fear are poorly understood.
Previous studies indicated that the acid sensing ion channel ASIC1a influences fear …

Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism,
and neuronal injury. This reduction in pH can have profound effects on brain function …

Patients who recover from pneumonia subsequently have elevated rates of death after hospital
discharge as a result of secondary organ damage, the causes of which are unknown. We …

Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as
brain ischemia, proton concentration can reach µM range. To respond to this increase in …

We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP)
(a permeant cAMP analog), and membrane depolarization promote spiral ganglion …

Acid-sensing ion channel-1a (ASIC1a) mediates H + -gated current to influence normal
brain physiology and impact several models of disease. Although ASIC2 subunits are widely …