We describe a new computer program, SnpEff, for rapidly categorizing the effects of variants
in genome sequences. Once a genome is sequenced, SnpEff annotates variants based on …

This paper describes a new program SnpSift for filtering differential DNA sequence variants
between two or more experimental genomes after genotoxic chemical exposure. Here, we …

Morphological alterations have been shown to occur in Drosophila melanogaster when
function of Hsp90 (heat shock 90-kDa protein 1α, encoded by Hsp83) is compromised during …

We report that the DNA methylation profile of a child’s neonatal whole blood can be
significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 …

Many environmental toxins, such as heavy metals, air particles, and ozone, induce oxidative
stress and decrease the levels of NADH and NADPH, cofactors that drive anabolic …

THE process of body prepatterning during Drosophila blastoderm formation relies on the
localized activities of zygotic segmentation genes, which are controlled by asymmetrically …

Hsp90 is a chaperone protein that interacts with client proteins that are known to be in the
cell cycle, signaling and chromatin-remodeling pathways. Hsp90 inhibitors act additively or …

Sperm of both mammals and invertebrates move toward specific sites in the female reproductive
tract. However, molecular mechanisms for sperm to follow directional cues are unknown…

Hsp90 is a chaperone for over 100 ‘client proteins’ in the cell, most of which are involved in
signaling pathways. For example, Hsp90 maintains several nuclear hormone receptors, such …

Green development strives to harmonize economic and social development with environmental
protection. It is an innovative development model for people to follow in response to …