Metabolic reprogramming in cancer cells facilitates growth and proliferation. Increased activity
of the serine biosynthetic pathway through the enzyme phosphoglycerate dehydrogenase …

In this work, microwave-assisted hydrothermal process was applied to modify the municipal
solid waste incineration (MSWI) fly ash and get zeolitic production. The condition of …

SARS-CoV-2 3C-like protease is the main protease of SARS-CoV-2 and has been considered
as one of the key targets for drug discovery against COVID-19. We identified several N-…

Elevated levels of the cyclin-dependent kinase (CDK) inhibitor p27 block the cell in G 0 /G 1
until mitogenic signals activate G 1 cyclins and initiate proliferation. Post-translational …

The kinase Mirk/dyrk1B mediated the clonogenic growth of pancreatic cancer cells in earlier
studies. It is now shown that Mirk levels increased 7-fold in SU86.86 pancreatic cancer cells …

The Rho family of small GTPases regulates numerous signaling pathways that control the
organization of the cytoskeleton, transcription factor activity, and many aspects of the …

Mirk/dyrk1B is a member of the dyrk/minibrain family of serine/threonine kinases that mediate
the transition from growth to differentiation in lower eukaryotes and mammals. Depletion of …

Regulating the upstream of the cytokines production could be a promising strategy to the
treatment of COVID-19. We suggest to pay more attention to the dysregulated IFN-I production …

Biomolecular condensates (biocondensates) formed via liquid–liquid phase-separation of
soluble proteins have been studied extensively. However, neither the phase-separation of …

Ductal adenocarcinoma of the pancreas is almost uniformly lethal as this cancer is invariably
detected at an advanced stage and is resistant to treatment. The serine/threonine kinase …