Pathogen-sugar interactions revealed by universal saturation transfer analysis

…, PI Koukos, MJ Davy, A Lakshminarayanan, X Xue… - Science, 2022 - science.org
Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan
ligands binding with heavily modified pathogen proteins can be confounded by overlapping …

Trehalose-6-phosphate signaling regulates lateral root formation in Arabidopsis thaliana

…, JD Sidda, JSO Mccullagh, X Xue… - Proceedings of the …, 2023 - National Acad Sciences
Plant roots explore the soil for water and nutrients, thereby determining plant fitness and
agricultural yield, as well as determining ground substructure, water levels, and global carbon …

Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage

…, NJ Bennett, R Reddy, A Khalil, X Xue… - Nature chemical …, 2021 - nature.com
The central dogma of biology does not allow for the study of glycans using DNA sequencing.
We report a liquid glycan array (LiGA) platform comprising a library of DNA ‘barcoded’ M13 …

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques

…, L Sibley, C Sarfas, G Pearson, E Rayner, X Xue… - Science …, 2021 - science.org
There is an urgent requirement for safe and effective vaccines to prevent COVID-19. A
concern for the development of new viral vaccines is the potential to induce vaccine-enhanced …

Glycans in HIV-1 vaccine design–engaging the shield

LP Deimel, X Xue, QJ Sattentau - Trends in Microbiology, 2022 - cell.com
Glycans are repeating carbohydrate structures added as post-translational modifications (PTMs)
to proteins, forming glycoproteins. Self-glycans found on human cells, and viral …

Synthesis of Unprecedented Sulfonylated Phosphono‐exo‐Glycals Designed as Inhibitors of the Three Mycobacterial Galactofuranose Processing Enzymes

…, W Pan, RB Zheng, A Koizumi, X Xue… - … A European Journal, 2016 - Wiley Online Library
This study reports a new methodology to synthesize exo‐glycals bearing both a sulfone and
a phosphonate. This synthetic strategy provides a way to generate exo‐glycals displaying …

Neoglycolipids as glycosphingolipid surrogates for protein binding studies using nanodiscs and native mass spectrometry

L Han, X Xue, R Roy, EN Kitova, RB Zheng… - Analytical …, 2020 - ACS Publications
Interactions between glycan-binding proteins (GBPs) and glycosphingolipids (GSLs) in the
membranes of cells are implicated in a wide variety of normal and pathophysiological …

A Carbohydrate-Based Approach for the Total Synthesis of (−)-Dinemasone B, (+)-4a-epi-Dinemasone B, (−)-7-epi-Dinemasone B, and (+)-4a,7-Di-epi-dinemasone …

X Xue, Z Yin, X Meng, Z Li - The Journal of Organic Chemistry, 2013 - ACS Publications
(−)-Dinemasone B was isolated by Krohn and co-workers from a culture of the endophytic
fungus Dinemasporium strigosum and has shown promising antimicrobial activity. Described …

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

…, A Giliberti, PI Koukos, A Lakshminarayanan, X Xue… - BioRxiv, 2021 - biorxiv.org
Many host pathogen interactions such as human viruses (including non-SARS-coronaviruses)
rely on attachment to host cell-surface glycans. There are conflicting reports about …

Synthetic polyprenol-pyrophosphate linked oligosaccharides are efficient substrates for mycobacterial galactan biosynthetic enzymes

X Xue, RB Zheng, A Koizumi, L Han… - Organic & …, 2018 - pubs.rsc.org
Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex
cell wall that is critical for their survival. The largest structural component of the cell wall, …