User profiles for Xiaohe Lin
 | Xiaohe LinThe Scripps Research Institute Verified email at scripps.edu Cited by 376 |
Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates
L He, X Lin, Y Wang, C Abraham, C Sou, T Ngo… - Science …, 2021 - science.org
Vaccination against SARS-CoV-2 provides an effective tool to combat the COVID-19 pandemic.
Here, we combined antigen optimization and nanoparticle display to develop vaccine …
Here, we combined antigen optimization and nanoparticle display to develop vaccine …
HIV-1 vaccine design through minimizing envelope metastability
Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here, we
present a coherent vaccine strategy by minimizing metastability. For 10 strains across five …
present a coherent vaccine strategy by minimizing metastability. For 10 strains across five …
Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are responsible for cell entry,
with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a …
with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a …
[HTML][HTML] Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
L He, A Chaudhary, X Lin, C Sou, T Alkutkar… - Nature …, 2021 - nature.com
Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs)
and is the main target for vaccine design. Here, we first investigate the contribution of the …
and is the main target for vaccine design. Here, we first investigate the contribution of the …
[HTML][HTML] Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans
Efficacy evaluation through human trials is crucial for advancing a vaccine candidate to
clinics. Next-generation sequencing (NGS) can be used to quantify B cell repertoire response …
clinics. Next-generation sequencing (NGS) can be used to quantify B cell repertoire response …
AVH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite
An oligomannose patch around the V3 base of HIV-1 envelope glycoprotein (Env) is recognized
by multiple classes of broadly neutralizing antibodies (bNAbs). Here, we investigated …
by multiple classes of broadly neutralizing antibodies (bNAbs). Here, we investigated …
[HTML][HTML] Phenotypic and methylome responses to salt stress in Arabidopsis thaliana natural accessions
X Lin, M Zhou, J Yao, QQ Li, YY Zhang - Frontiers in Plant Science, 2022 - frontiersin.org
Salt stress threatens plant growth, development and crop yields, and has become a critical
global environmental issue. Increasing evidence has suggested that the epigenetic …
global environmental issue. Increasing evidence has suggested that the epigenetic …
Genotypic variation of transgenerational plasticity can be explained by environmental predictability at origins
J Yin, X Lin, J Yao, QQ Li, YY Zhang - Oikos, 2022 - Wiley Online Library
Transgenerational plasticity is the plastic response of offspring to ancestral environments.
Theoretical studies and experimental evolution have demonstrated the importance of …
Theoretical studies and experimental evolution have demonstrated the importance of …
[PDF][PDF] Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins
Human IGHV1-69-encoded broadly neutralizing antibodies (bnAbs) that target the hepatitis
C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV …
C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV …
Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers
Broadly neutralizing antibodies (bNAbs) have provided valuable insights into the humoral
immune response to HIV-1. While rationally designed epitope scaffolds and well-folded gp140 …
immune response to HIV-1. While rationally designed epitope scaffolds and well-folded gp140 …