[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells
…, S Rowlston, SP Wilder, S Farrow, X Shao… - Cell, 2016 - cell.com
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…
phenotypes is a major challenge in human genetics and medicine. We carried out high-…
GenPipes: an open-source framework for distributed and scalable genomic analyses
…, D Anderson de Lima Morais, J Tremblay, X Shao… - …, 2019 - academic.oup.com
Background With the decreasing cost of sequencing and the rapid developments in genomics
technologies and protocols, the need for validated bioinformatics software that enables …
technologies and protocols, the need for validated bioinformatics software that enables …
[PDF][PDF] Aging-like spontaneous epigenetic silencing facilitates Wnt activation, stemness, and BrafV600E-induced tumorigenesis
We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation
in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter …
in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter …
Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes
Triclosan (TCS), an extensively used antimicrobial agent, has raised considerable concern
due to its hepatocarcinogenic potential. However, previous hepatotoxicity studies primarily …
due to its hepatocarcinogenic potential. However, previous hepatotoxicity studies primarily …
[HTML][HTML] Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted
arrays or enrichment methodologies preferentially covering CpG-dense regions, to …
arrays or enrichment methodologies preferentially covering CpG-dense regions, to …
[HTML][HTML] Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation
Background CpG methylation variation is involved in human trait formation and disease
susceptibility. Analyses within populations have been biased towards CpG-dense regions …
susceptibility. Analyses within populations have been biased towards CpG-dense regions …
[HTML][HTML] Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome
Background The functional impact of genetic variation has been extensively surveyed, revealing
that genetic changes correlated to phenotypes lie mostly in non-coding genomic regions…
that genetic changes correlated to phenotypes lie mostly in non-coding genomic regions…
[HTML][HTML] The impact of lockdown timing on COVID-19 transmission across US counties
Background Many countries have implemented lockdowns to reduce COVID-19 transmission.
However, there is no consensus on the optimal timing of these lockdowns to control …
However, there is no consensus on the optimal timing of these lockdowns to control …
The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation
The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment of …
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment of …
NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis
The 5′ end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m 7 G)
cap that protects mRNA from degradation and mediates almost all other aspects of gene …
cap that protects mRNA from degradation and mediates almost all other aspects of gene …