Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While
efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and …

Nucleic acid detection methods are crucial for many fields such as pathogen detection and
genotyping. Solid-state nanopore sensors represent a promising platform for nucleic acid …

The outbreak of the SARS-CoV-2 caused the disease COVID-19 to spread globally. Specific
and sensitive detection of SARS-CoV-2 facilitates early intervention and prevents the …

Immunotherapy is a powerful technique where immune cells are modified to improve cytotoxicity
against cancerous cells to treat cancers that do not respond to surgery, chemotherapy, …

Cardiovascular disease, ranging from congenital heart disease to adult myocardial infarction,
is the leading cause of death worldwide. In pursuit of reliable cardiovascular regenerative …

CRISPR systems have revolutionized biomedical research because they offer an unprecedented
opportunity for genome editing. However, a bottleneck of applying CRISPR systems in …

Neutrophils, a key innate immune component, are powerful effector leukocytes for mediating
opposing effects on tumor progression and ameliorating pathogen infections. However, …

Adoptive chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have shown
promise in treating various cancers. However, limited immunological memory and access to …

Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) provide promising
cell therapies for type 1 diabetes. Current PP differentiation requires a high amount of …

CRISPR/Cas-mediated genome editing in human pluripotent stem cells (hPSCs) offers
unprecedented opportunities for developing in vitro disease modeling, drug screening and cell-…