User profiles for Xiaoliang Sunney Xie
 | Xiaoliang Sunney XieLee Shau Kee Professor of Peking University Verified email at pku.edu.cn Cited by 72414 |
Single-cell whole-genome amplification and sequencing: methodology and applications
We present a survey of single-cell whole-genome amplification (WGA) methods, including
degenerate oligonucleotide–primed polymerase chain reaction (DOP-PCR), multiple …
degenerate oligonucleotide–primed polymerase chain reaction (DOP-PCR), multiple …
[HTML][HTML] Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding
domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires …
domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires …
[HTML][HTML] BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …
[BOOK][B] Coherent Raman scattering microscopy
The First Book on CRS MicroscopyCompared to conventional Raman microscopy, coherent
Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by …
Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by …
[HTML][HTML] Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
…, F Shao, X Hao, Y Xu, R Jin, Z Shen, Y Wang, XS Xie - Nature, 2023 - nature.com
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA.5 (ref. ). Despite their divergent …
numerous variants that display growth advantages over BA.5 (ref. ). Despite their divergent …
[PDF][PDF] Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
…, W Fu, T Chu, L Feng, Y Wang, X Pei, P Yang, XS Xie… - Cell, 2022 - cell.com
The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly worldwide.
Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid substitutions …
Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid substitutions …
[PDF][PDF] Characterization of the enhanced infectivity and antibody evasion of Omicron BA. 2.75
Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage
over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms …
over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms …
[PDF][PDF] Circular RNA vaccines against SARS-CoV-2 and emerging variants
As the emerging variants of SARS-CoV-2 continue to drive the worldwide pandemic, there
is a constant demand for vaccines that offer more effective and broad-spectrum protection. …
is a constant demand for vaccines that offer more effective and broad-spectrum protection. …
[HTML][HTML] Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
…, L Yu, Z Lv, Q Gu, F Shao, R Jin, Z Shen, XS Xie… - Nature, 2024 - nature.com
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …
vaccine compositions. However, immune imprinting induced by vaccination based on the …
[PDF][PDF] Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells
Natural variations in gene expression provide a mechanism for multiple phenotypes to arise
in an isogenic bacterial population. In particular, a sub-group termed persisters show high …
in an isogenic bacterial population. In particular, a sub-group termed persisters show high …