User profiles for Xiaolin Cheng
 | Xiaolin ChengProfessor, The Ohio State University Verified email at osu.edu Cited by 5494 |
Enantioselective electrophilic trifluoromethylthiolation of β-ketoesters: a case of reactivity and selectivity bias for organocatalysis.
A chiral Lewis base or a phase‐transfer catalyst (PTC) can mediate the highly enantioselective
trifluoromethylthiolation of β‐ketoesters with the previously developed SCF3 reagent (see …
trifluoromethylthiolation of β‐ketoesters with the previously developed SCF3 reagent (see …
[HTML][HTML] The dynamics of single protein molecules is non-equilibrium and self-similar over thirteen decades in time
Internal motions of proteins are essential to their function. The time dependence of protein
structural fluctuations is highly complex, manifesting subdiffusive, non-exponential behaviour …
structural fluctuations is highly complex, manifesting subdiffusive, non-exponential behaviour …
[HTML][HTML] The in vivo structure of biological membranes and evidence for lipid domains
Examining the fundamental structure and processes of living cells at the nanoscale poses a
unique analytical challenge, as cells are dynamic, chemically diverse, and fragile. A case in …
unique analytical challenge, as cells are dynamic, chemically diverse, and fragile. A case in …
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth
Tumorigenesis is associated with elevated glucose and glutamine consumption, but how
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal that …
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal that …
Order N algorithm for computation of electrostatic interactions in biomolecular systems
Poisson–Boltzmann electrostatics is a well established model in biophysics; however, its
application to large-scale biomolecular processes such as protein–protein encounter is still …
application to large-scale biomolecular processes such as protein–protein encounter is still …
Biological membrane organization and cellular signaling
To execute their many vital functions, cell membranes are highly organized. Here, we
review how membrane structure shapes signal transduction across membranes. Recent …
review how membrane structure shapes signal transduction across membranes. Recent …
Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes
Understanding of cell membrane organization has evolved significantly from the classic
fluid mosaic model. It is now recognized that biological membranes are highly organized …
fluid mosaic model. It is now recognized that biological membranes are highly organized …
Cosolvent pretreatment in cellulosic biofuel production: effect of tetrahydrofuran-water on lignin structure and dynamics
The deconstruction of cellulose is an essential step in the production of ethanol from
lignocellulosic biomass. However, the presence of lignin hinders this process. Recently, a novel …
lignocellulosic biomass. However, the presence of lignin hinders this process. Recently, a novel …
Mechanical properties of nanoscopic lipid domains
The lipid raft hypothesis presents insights into how the cell membrane organizes proteins and
lipids to accomplish its many vital functions. Yet basic questions remain about the physical …
lipids to accomplish its many vital functions. Yet basic questions remain about the physical …
Characterizing loop dynamics and ligand recognition in human-and avian-type influenza neuraminidases via generalized born molecular dynamics and end-point free …
The comparative dynamics and inhibitor binding free energies of group-1 and group-2
pathogenic influenza A subtype neuraminidase (NA) enzymes are of fundamental biological …
pathogenic influenza A subtype neuraminidase (NA) enzymes are of fundamental biological …