The incidence of melanoma is increasing more than any other cancer, and knowledge of its
genetic alterations is limited. To systematically analyze such alterations, we performed whole…

Appropriate cell number and organ size in a multicellular organism are determined by
coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause …

To better understand the molecular mechanisms and genetic basis of human disease, we
systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 …

The Hippo pathway plays a key role in organ size control by regulating cell proliferation and
apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo …

Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in noncoding …

Tyrosine phosphorylation is important in signaling pathways underlying tumorigenesis. We
performed a mutational analysis of the protein tyrosine kinase (PTK) gene family in …

Tissue growth and organ size are determined by coordinated cell proliferation and apoptosis
in development. Recent studies have demonstrated that Hippo (Hpo) signaling plays a …

Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683–691]. …

Microphthalmia‐associated transcription factor (MITF) is involved in melanocyte cell
development, pigmentation and neoplasia. To determine whether MITF is somatically mutated in …

G protein-coupled receptors (GPCRs), the largest human gene family, are important regulators
of signaling pathways. However, knowledge of their genetic alterations is limited. In this …