Topologically associating domains (TADs), CTCF loop domains, and A/B compartments
have been identified as important structural and functional components of 3D chromatin …

Chromosomes of metazoan organisms are partitioned in the interphase nucleus into discrete
topologically associating domains (TADs). Borders between TADs are formed in regions …

The mammalian sperm genome is thought to lack substantial information for the regulation of
future expression after fertilization. Here, we show that most promoters in mouse sperm are …

Eukaryotic gene expression is regulated by enhancer–promoter interactions but the molecular
mechanisms that govern specificity have remained elusive. Genome-wide studies utilizing …

Pluripotent genomes are folded in a topological hierarchy that reorganizes during
differentiation. The extent to which chromatin architecture is reconfigured during somatic cell …

The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin
modifications and three-dimensional genome architecture; however, causal links have not …

Interaction domains in Drosophila chromosomes form by segregation of active and inactive
chromatin in the absence of CTCF loops, but the role of transcription versus other …

The epigenetic information present in mammalian gametes and whether it is transmitted to
the progeny are relatively unknown. We find that many promoters in mouse sperm are …

Cells respond to temperature stress via up- and downregulation of hundreds of genes. This
process is thought to be regulated by the heat shock factor HSF1, which controls the release …

Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc
is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak …