During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted
into the activated spliceosome (B act complex), which has a well-formed active site but …

Splicing by the spliceosome involves branching and exon ligation. The branching reaction
leads to the formation of the catalytic step I spliceosome (C complex). Here we report the cryo–…

The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B
complex) and followed by the activated spliceosome (B act complex). The pre-B-to-B and B-to…

Wntless (WLS), an evolutionarily conserved multi-pass transmembrane protein, is essential
for secretion of Wnt proteins. Wnt-triggered signaling pathways control many crucial life …

Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is
mediated by the spliceosome. Together with biochemical and genetic investigations of the past …

SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression.
Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex …

INTRODUCTION The nuclear pore complex (NPC) resides on the nuclear envelope (NE) and
mediates nucleocytoplasmic cargo transport. As one of the largest cellular machineries, a …

SIN3–HDAC (histone deacetylases) complexes have important roles in facilitating local histone
deacetylation to regulate chromatin accessibility and gene expression. Here, we present …

Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of
life. In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) …

The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential
roles in regulating chromatin accessibility and gene expression. There are two major types of …