Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of electrical …

Polyetheretherketone (PEEK) has been an alternative material for titanium in bone defect
repair, but its clinical application is limited by its poor osseointegration. In this study, a porous …

Bone defect repair at load-bearing sites is a challenging clinical problem for orthopedists.
Defect reconstruction with implants is the most common treatment; however, it requires the …

Although magnesium and its alloys are candidates for orthopedic implants, they can
effectively promote osteogenesis and angiogenesis. However, due to the degradability of …

Background Diabetes mellitus (DM) is considered to be an important factor for bone degeneration
disorders such as bone defect nonunion, which is characterized by physical disability …

Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can significantly
reduce stress shielding and contribute to better bone repair than the conventional Ti6Al4V …

Early vascularization plays an important role in bone healing, especially in interfacial bone
formation. Many modifications have been made to titanium surfaces to promote angiogenesis…

Biodegradable polycaprolactone/β-tricalcium phosphate (PT) composites are desirable
candidates for bone tissue engineering applications. A higher β-tricalcium phosphate (TCP) …

… Zhen Tang, Hui Dong, Tian Li, Ning Wang, Wei Wang, and Xin Xiao acquired the data.
Zhen Tang, Zheng Guo, and Xinghui Wei analysed the data and drafted the manuscript. Zhen …

Porous titanium scaffolds can provide sufficient mechanical support and bone growth space
for large segmental bone defect repair. However, they fail to restore the physiological …