Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats
X Liu, JP Chism, EL LeCluyse, KR Brouwer… - Drug Metabolism and …, 1999 - ASPET
The relationship between biliary excretion in sandwich-cultured rat hepatocytes and in vivo
in rats was examined. The biliary excretion of seven model substrates in 96-h sandwich-…
in rats was examined. The biliary excretion of seven model substrates in 96-h sandwich-…
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …
Development of a computational approach to predict blood-brain barrier permeability
X Liu, M Tu, RS Kelly, C Chen, BJ Smith - Drug metabolism and disposition, 2004 - ASPET
The objectives of this study were to generate a data set of blood-brain barrier (BBB) permeability
values for drug-like compounds and to develop a computational model to predict BBB …
values for drug-like compounds and to develop a computational model to predict BBB …
Effect of high salinity on activated sludge characteristics and membrane permeability in an immersed membrane bioreactor
E Reid, X Liu, SJ Judd - Journal of membrane science, 2006 - Elsevier
The influence of high salinity on the characteristics of the activated sludge and performance
of a pilot-scale immersed membrane bioreactor (iMBR) has been studied. The bioreactor …
of a pilot-scale immersed membrane bioreactor (iMBR) has been studied. The bioreactor …
Rational use of plasma protein and tissue binding data in drug design: miniperspective
It is a commonly accepted assumption that only unbound drug molecules are available to
interact with their targets. Therefore, one of the objectives in drug design is to optimize the …
interact with their targets. Therefore, one of the objectives in drug design is to optimize the …
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
…, CECA Hop, IN Kasman, J LaPerle, JH Liu, X Liu… - Drug Metabolism and …, 2005 - ASPET
Thirty-two structurally diverse drugs used for the treatment of various conditions of the central
nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were …
nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were …
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
…, DJ Burdick, J Gunzner-Toste, H Chen, X Liu… - Science translational …, 2012 - science.org
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of
familial Parkinson’s disease (PD). Although biochemical studies have shown that certain PD …
familial Parkinson’s disease (PD). Although biochemical studies have shown that certain PD …
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
…, DW Lee, SC Lewin-Koh, T Lin, X Liu, S Liu… - Science translational …, 2015 - science.org
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation
as a possible treatment for Parkinson’s disease. However, there is no clinical validation as …
as a possible treatment for Parkinson’s disease. However, there is no clinical validation as …
Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration
X Liu, EL LeCluyse, KR Brouwer… - American Journal …, 1999 - journals.physiology.org
The objective of the present investigation was to examine the functional reestablishment of
polarity in freshly isolated hepatocytes cultured between 2 layers of gelled collagen (…
polarity in freshly isolated hepatocytes cultured between 2 layers of gelled collagen (…
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier …
X Liu, BJ Smith, C Chen, E Callegari, SL Becker… - … of Pharmacology and …, 2005 - ASPET
This study was designed 1) to examine the effects of blood-brain barrier (BBB) permeability [quantified
as permeability-surface area product (PS)], unbound fraction in plasma (f u,…
as permeability-surface area product (PS)], unbound fraction in plasma (f u,…