Degradation and collapse of stalled replication forks are main sources of genomic instability,
yet the molecular mechanisms for protecting forks from degradation/collapse are not well …

Replication stress causes replication fork stalling, resulting in an accumulation of single-stranded
DNA (ssDNA). Replication protein A (RPA) and CTC1-STN1-TEN1 (CST) complex …

The human CST (CTC1-STN1-TEN1) complex is an RPA-like single-stranded DNA binding
protein complex. While its telomeric functions have been well investigated, numerous studies …

Background Replication stress (RS) gives rise to DNA damage that threatens genome
stability. RS can originate from different sources that stall replication by diverse mechanisms. …

DNA replication stress, caused by various endogenous and exogenous agents, halt or stall
DNA replication progression. Cells have developed diverse mechanisms to tolerate and …

Sorbicillinoids (also termed yellow pigment) are derived from either marine or terrestrial fungi,
exhibit various biological activities and therefore show potential as commercial products …

Esophageal squamous cell carcinoma (ESCC) is a prevalent and highly lethal malignant
disease. The epithelial-mesenchymal transition (EMT) is crucial in promoting ESCC …

Protein arginine methylation is a common post-translational modification involved in the
regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (…

Degradation and collapse of stalled replication forks are main sources of genome instability,
yet the molecular mechanism for protecting forks from degradation/collapse is not well …

Background: Frequently, subcellular-targeted drugs tend to accumulate in lysosomes after
cellular absorption, a process termed the lysosomal trap. This accumulation often interferes …