Mast cells are primary effectors in allergic reactions, and may have important roles in disease
by secreting histamine and various inflammatory and immunomodulatory substances 1 , 2 . …

In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled
receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Itch-specific neurons have been sought for decades. The existence of such neurons has been
doubted recently as a result of the observation that itch-mediating neurons also respond to …

Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching
and type 2 immunity-associated hypersensitivity to widely distributed allergens, including …

… The work was supported by a grant from the NIH to Xinzhong Dong (R01NS054791) and
a … Foundation and the Howard Hughes Medical Institute (DRG-2295-17) to Xintong Dong. …

Mast cells can be found in close proximity to peripheral nerve endings where, upon activation,
they release a broad range of pro-inflammatory cytokines and chemokines. However, the …

Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations
of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch …

Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin
and nervous system disorders. In many cases, pathological itch is insensitive to …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. Disease
alleles contain a trinucleotide repeat expansion of variable length, which encodes …