We report the sequence and analysis of the 814-megabase genome of the sea urchin
Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing …

Retinal ganglion cells (RGCs) are the first cell type to be specified during vertebrate retinogenesis.
Specification and differentiation of the RGC lineage are a stepwise process involving …

Ramalho-Santos et al.(1) and Ivanova et al.(2), comparing the same three “stem cells”—embryonic
stem cells (ESCs); neural stem cells (NSCs), referred to as neural progenitor/stem …

Vascularization is essential for tissue development and in restoration of tissue integrity after
an ischemic injury. In studies of vascularization, the focus has largely been placed on …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact. …

Retinal ganglion cells (RGCs) are the only projection neurons in the neural retina. They
receive and integrate visual signals from upstream retinal neurons in the visual circuitry and …

Understanding gene regulatory networks (GRNs) that control neuronal differentiation will
provide systems-level perspectives on neurogenesis. We have previously constructed a model …

Math5, a mouse homolog of the Drosophila proneural bHLH transcription factor Atonal, is
essential in the developing retina to establish retinal progenitor cell competence for a ganglion …

Previously, we have shown that Onecut1 (Oc1) and Onecut2 (Oc2) are expressed in retinal
progenitor cells, developing retinal ganglion cells (RGCs), and horizontal cells (HCs). …

In mice, Brn3 POU domain transcription factors play essential roles in the differentiation and
survival of projection neurons within the retina, inner ear, dorsal root and trigeminal ganglia. …