Mouse spermatozoa express a pH-dependent K + current (KSper) thought to be composed
of subunits encoded by the Slo3 gene. However, the equivalence of KSper and Slo3-…

A family of accessory β subunits significantly contributes to the functional diversity of large-conductance,
Ca 2+ - and voltage-dependent potassium (BK) channels in native cells. Here …

Mutational analyses have suggested that BK channels are regulated by three distinct divalent
cation-dependent regulatory mechanisms arising from the cytosolic COOH terminus of the …

Mitochondrial anti-viral signaling (MAVS) protein is a critical adaptor required for innate
immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like …

Adhesion G protein-coupled receptors are elusive in terms of their structural information and
ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo-…

Background: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor,
is known to exert toxic effects on the testes. However, the mechanisms accounting for its …

STUDY QUESTION Are genetic abnormalities in CATSPER (cation channel of sperm) genes
associated with idiopathic male infertility with normal semen parameters and, if so, how do …

Background and Purpose Sperm from many species share the sperm‐specific Ca 2+ channel
CatSper that controls the intracellular Ca 2+ concentration and, thereby, the swimming …

KSper, a pH-dependent K + current in mouse spermatozoa that is critical for fertility, is activated
by alkalization in the range of pH 6.4–7.2 at membrane potentials between −50 and 0 mV…

… Xu-Hui Zeng Xu-Hui Zeng 2 … Hua-Feng Wang, Min Liu, Na Li, Tao Luo, Li-Ping Zheng,
Xu-Hui Zeng, Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism, …