Background A protein that is expressed on capillary endothelial cells, called GPIHBP1 (glycosylphosphatidylinositol-anchored
high-density lipoprotein binding protein 1), binds …

Cardiac left ventricular outflow tract (LVOT) defects represent a common but heterogeneous
subset of congenital heart disease for which gene identification has been difficult. We …

Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent
biochemical studies showed that one pool of cholesterol in the plasma membrane is “accessible” …

Pregnancy is a physiological process with pronounced hormonal fluctuations in females,
and relatively little is known regarding how pregnancy influences the ecological shifts of …

The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital
tissues, but our understanding of TRL metabolism is limited, in part because TRL processing …

Background Controlling the adipo-osteogenic lineage commitment of bone marrow
mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for …

Gold nanoparticles (AuNPs) are a promising material for use in regenerative medicine due
to their biocompatibility and easy functionalization with biomolecules including growth factors…

Macrophages are generally assumed to unload surplus cholesterol through direct interactions
between ABC transporters on the plasma membrane and HDLs, but they have also been …

10.7554/eLife.38337.001 Anhydrobiotes are rare microbes, plants and animals that tolerate
severe water loss. Understanding the molecular basis for their desiccation tolerance may …

Emerging evidence indicates extensive oxidative stress is a consequence of obesity which
impairs bone formation. Glutathione peroxidase 7 (GPX7) is a conserved endoplasmic …