Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-secreting
cells. What underlies the function of the islet as a unit is the close approximation and …

Super-resolution microscopy and single molecule fluorescence spectroscopy require
mutually exclusive experimental strategies optimizing either temporal or spatial resolution. To …

Wnt3 is a morphogen that activates the Wnt signaling pathway and regulates a multitude of
biological processes ranging from cell proliferation and cell fate specification to differentiation …

Glucagon hypersecretion from pancreatic islet α-cells exacerbates hyperglycemia in type 1
diabetes (T1D) and type 2 diabetes. Still, the underlying mechanistic pathways that regulate …

Hyperinsulinemia often precedes type 2 diabetes. Palmitoylation, implicated in exocytosis,
is reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …

Blood glucose homeostasis requires proper function of pancreatic islets, which secrete insulin,
glucagon and somatostatin from the β-, α-and δ-cells respectively. Each islet cell type is …

The plasma membrane organization of live cells defines a plethora of cellular processes
important for cell functionality. Many membrane structures that define this organization exist at a …

Newly synthesized proteins constitute an important subset of the proteome involved in every
cellular process, yet existing chemical tools used to study them have major shortcomings. …

Imaging fluorescence correlation spectroscopy (FCS) and the related FCS diffusion law
have been applied in recent years to investigate the diffusion modes of lipids and proteins in …

The K + channel selectivity filter (SF) is defined by TxGYG amino acid sequences that
generate four identical K + binding sites (S1-S4). Only two sites (S3, S4) are present in the non-…