Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high
mortality and mobility. Although the mortality of SAH has decreased by 50% over the past …

The water-soluble Nrf2 (nuclear factor, erythroid 2-like 2, also called Nfe2l2) is accepted as
a master regulator of antioxidant responses to cellular stress, and it was also identified as a …

The full-length Nrf1α is processed into distinct isoforms, which together regulate genes essential
for maintaining cellular homeostasis and organ integrity and liver-specific loss of Nrf1 in …

Our previous work revealed that Nrf1α exerts a tumor-repressing effect because its genomic
loss (to yield Nrf1α -/- ) results in oncogenic activation of Nrf2 and target genes. Interestingly, …

Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non-
alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the …

Insufficient remyelination due to impaired oligodendrocyte precursor cell (OPC) differentiation
and maturation is strongly associated with irreversible white matter injury (WMI) and …

Hemostatic sealant is required to deal with blood loss, especially in the scenario of traumatic
brain injury (TBI), which presents high rates of morbidity and disability. Hemostasis in …

The single Nrf1 gene has capability to be differentially transcripted alongside with alternative
mRNA-splicing and subsequent translation through different initiation signals so as to yield …

Introduction Central nervous system (CNS) diseases, such as neurodegenerative disorders
and brain diseases caused by acute injuries, are important, yet challenging to study due to …

Hydrocephalus is a severe complication that can result from intracerebral hemorrhage,
especially if this hemorrhage extends into the ventricles. Our previous study indicated that the …