The decrease of TCR diversity with aging has never been studied by direct methods. In this
study, we combined high-throughput Illumina sequencing with unique cDNA molecular …

Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in
antigen recognition during the adaptive immune response. Recent progress in next-generation …

The TCR repertoire is a mirror of the human immune system that reflects processes caused
by infections, cancer, autoimmunity, and aging. Next generation sequencing (NGS) is …

High-throughput sequencing has the power to reveal the nature of adaptive immunity as
represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at …

COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key
role in the adaptive antiviral immune response by killing infected cells and facilitating the …

Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface
of B and T cells. The final set of these molecules in each organism is formed under the …

Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast
diversity of pathogen-derived antigens. Our ability to extract clinically relevant information …

The diversity of T-cell receptors recognizing foreign pathogens is generated through a
highly stochastic recombination process, making the independent production of the same …

Emerging high-throughput sequencing methods for the analyses of complex structure of TCR
and BCR repertoires give a powerful impulse to adaptive immunity studies. However, there …

T cell receptor (TCR) repertoire data contain information about infections that could be used
in disease diagnostics and vaccine development, but extracting that information remains a …