Giant cell arteritis (GCA) is an important cause of preventable blindness, most commonly due
to anterior ischemic optic neuropathy. Ischemic tissue injury is the end result of a process …

The small GTPases of the Rac/Rho/Cdc42 subfamily are implicated in actin cytoskeleton-membrane
interaction in mammalian cells and budding yeast. The in vivo functions of these …

Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related
restructuring of the immune system and age-induced remodeling of the vascular wall. …

Background Current staging methods do not accurately predict the risk of disease recurrence
and benefit of adjuvant chemotherapy for patients who have had surgery for stage II colon …

Context Pain commonly occurs in people living with dementia but is often undertreated. Non-pharmacological
interventions are a safer first-line option for pain management, but …

Background Recent profile studies of microRNA (miRNA) expression have documented a
deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). Objective To determine …

G protein-gated, inwardly rectifying K + channels (GIRK) are effectors of G protein-coupled
receptors for neurotransmitters and hormones and may play an important role in the …

A WIDE variety of voltage-gated K + channels are involved in the regulation of neuronal
excitability and synaptic transmission. Their heterogeneity arises in part from the large number of …

The enhancer of zeste homolog 2 (EZH2) is upregulated and has an oncogenic role in
several types of human cancer. However, the abnormalities of EZH2 and its underlying …

The weaver (wv) gene (GIRK2) is a member of the G-protein-gated inwardly rectifying
potassium (GIRK) channel family, known effectors in the signal transduction pathway of …