Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis
Importance The association of nonmotor features and Parkinson disease (PD) is increasingly
recognized. Evidence suggests that inflammation may play a role in PD pathologic features …
recognized. Evidence suggests that inflammation may play a role in PD pathologic features …
The extended granin family: structure, function, and biomedical implications
… Peng Loh , … Peng Loh … Peng Loh, Stephen RJ Salton, The Extended Granin Family:
Structure, Function, and Biomedical Implications, Endocrine Reviews, Volume 32, Issue 6, 1 …
Structure, Function, and Biomedical Implications, Endocrine Reviews, Volume 32, Issue 6, 1 …
Dense-core secretory granule biogenesis
…, MC Gondré-Lewis, I Arnaoutova, YP Loh - Physiology, 2006 - journals.physiology.org
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides
in endocrine cells and neurons, in response to stimulation. Cholesterol and granins …
in endocrine cells and neurons, in response to stimulation. Cholesterol and granins …
[HTML][HTML] Chromogranin A, an “on/off” switch controlling dense-core secretory granule biogenesis
We present evidence that regulation of dense-core secretory granule biogenesis and hormone
secretion in endocrine cells is dependent on chromogranin A (CGA). Downregulation of …
secretion in endocrine cells is dependent on chromogranin A (CGA). Downregulation of …
[HTML][HTML] Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpefat mice
…, F Shen, HC Chen, L Pannell, Y Zhang, YP Loh - Cell, 1997 - cell.com
A proposed mechanism for sorting secretory proteins into granules for release via the regulated
secretory pathway in endocrine-neuroendocrine cells involves binding the proteins to a …
secretory pathway in endocrine-neuroendocrine cells involves binding the proteins to a …
Getting to know low-light images with the exclusively dark dataset
Low-light is an inescapable element of our daily surroundings that greatly affects the
efficiency of our vision. Research works on low-light imagery have seen a steady growth, …
efficiency of our vision. Research works on low-light imagery have seen a steady growth, …
[HTML][HTML] Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e
H Lou, SK Kim, E Zaitsev, CR Snell, B Lu, YP Loh - Neuron, 2005 - cell.com
Activity-dependent secretion of BDNF is important in mediating synaptic plasticity, but how it
is achieved is unclear. Here we uncover a sorting motif receptor-mediated mechanism for …
is achieved is unclear. Here we uncover a sorting motif receptor-mediated mechanism for …
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Reduced food intake brings about an adaptive decrease in energy expenditure that contributes
to the recidivism of obesity after weight loss. Insulin and leptin inhibit food intake through …
to the recidivism of obesity after weight loss. Insulin and leptin inhibit food intake through …
[HTML][HTML] 60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides
… In follow-up studies, Loh and colleagues coupled the N-POMC(1–26) peptide, containing
the sorting signal motif of POMC, to beads and used it in affinity chromatography using NIL …
the sorting signal motif of POMC, to beads and used it in affinity chromatography using NIL …
[HTML][HTML] H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …