Naïve and primed pluripotent states retain distinct molecular properties, yet limited knowledge
exists on how their state transitions are regulated. Here, we identify Mettl3, an N 6 -…

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …

Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …

Aneuploidy, an abnormal number of chromosomes, is a widespread phenomenon found in
unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer. …

Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive
pluripotency characteristics while maintaining differentiation competence and (epi)genetic …

Pluripotency is first assembled within the inner-cell-mass of developing pre-implantation
blastocysts, and is gradually reconfigured and dismantled during early post-implantation …

… Manor,1 Vladislav Krupalnik,1 Mirie Zerbib,1 Hadas Hezroni,3 Diego Adhemar Jaitin,8 David
… YS assisted in RGM reporter experiments. YR, LW, and NM engineered cell lines under SV …

Background Previous work showed that mRNA degradation is coordinated with transcription
in yeast, and in several genes the control of mRNA degradation was linked to promoter …

… Manor and Jacob H. Hanna … Manor and Jacob H. Hanna are at the Department of
Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Jacob H. …

… YS generated and advised on conducting experiments involving RGM reporters. YR and
NM engineered cell lines under SV supervision and designs. NN and JHH supervised …