Most current therapies that target plasma membrane receptors function by antagonizing
ligand binding or enzymatic activities. However, typical mammalian proteins comprise multiple …

Cell fate decision upon prolonged mitotic arrest induced by microtubule-targeting agents
depends on the activity of the tumor suppressor and F-box protein FBXW7. FBXW7 promotes …

Correct spindle orientation is achieved through signaling pathways that provide a molecular
link between the cell cortex and spindle microtubules in an F-actin-dependent manner. A …

Microtubule nucleation was uncovered as a key principle of spindle assembly. However, the
mechanistic details about microtubule nucleation and the organization of spindle formation …

Selective and precise activation of signaling transduction cascades is key for cellular
reprogramming and tissue regeneration. However, the development of small- or large-molecule …

… Yvonne Kschonsak is the first author on ‘ Activated ezrin controls MISP levels to ensure
correct NuMA polarization and spindle orientation ’, published in Journal of Cell Science. …

Extensive biological and clinical evidence supports the notion many CRC tumors are addicted
to EGFR/KRAS/MAPK signaling. For example, mutations in KRAS, BRAF and other MAPK …

Genomic studies performed in cancer patients have identified a high frequency of
alterations in the core catalytic subunit of the mammalian switch/sucrose non-fermentable (mSWI/SNF) …

During prolonged mitotic arrest induced by antimicrotubule drugs, cell fate decision is
determined by two alternative pathways, one leading to cell death and the other inducing …

Microvilli are conserved actin-based surface protrusions that have been repurposed throughout
evolution to fulfill diverse cell functions. In the case of transporting epithelia, microvilli are …