To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed
massively parallel whole-exome sequencing of 55 primary tumor samples from patients …

Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations,
some of which are causally involved in tumorigenesis (drivers) and others that have little …

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease,
is abundantly expressed in both the brain and periphery. Here, we present evidence that …

APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD).
To address the underlying mechanism, we develop cerebral organoid models using …

Background Although the costs of next generation sequencing technology have decreased
over the past years, there is still a lack of simple-to-use applications, for a comprehensive …

Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes
with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been …

Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span.
CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-…

We investigated whether previously reported muscle mitochondrial dysfunction and altered
gene transcript levels in type 2 diabetes might be secondary to abnormal blood glucose and …

Purpose: Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin
lymphoma confined to the central nervous system. Whether there is a PCNSL-specific …

… Asmann, Krishna R. Kalari, Jeanette E. Eckel-Passow, Amylou C. … Asmann, Krishna R.
Kalari, Amylou C. Dueck, Kathleen S. … Asmann …