User profiles for Y. Chhabra

Yash Chhabra

FoxChase Cancer Center
Verified email at fccc.edu
Cited by 1170

Fibroblasts in cancer: Unity in heterogeneity

Y Chhabra, AT Weeraratna - Cell, 2023 - cell.com
Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Cardiovascular disease in patients with chronic kidney disease: a neglected subgroup

AK Subbiah, YK Chhabra, S Mahajan - Heart Asia, 2016 - heartasia.bmj.com
The burden of non-communicable diseases has increased exponentially over the past decade
and they account for majority of the health-related morbidity and mortality worldwide. In …

Role of the growth hormone–IGF-1 axis in cancer

Y Chhabra, MJ Waters, AJ Brooks - Expert review of endocrinology …, 2011 - Taylor & Francis
A substantial body of evidence supports a role for the growth hormone (GH)–IGF-1 axis in
cancer incidence and progression. This includes epidemiological evidence relating elevated …

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

AJ Brooks, W Dai, ML O'Mara, D Abankwa, Y Chhabra… - Science, 2014 - science.org
Introduction Class I cytokines regulate key processes such as growth, lactation, hematopoiesis,
and immune function and contribute to oncogenesis. Although the extracellular domain …

Stromal changes in the aged lung induce an emergence from melanoma dormancy

ME Fane, Y Chhabra, GM Alicea, DA Maranto… - Nature, 2022 - nature.com
Disseminated cancer cells from primary tumours can seed in distal tissues, but may take several
years to form overt metastases, a phenomenon that is termed tumour dormancy. Despite …

[HTML][HTML] NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF

ME Fane, Y Chhabra, DEJ Hollingsworth… - …, 2017 - thelancet.com
While invasion and metastasis of tumour cells are the principle factor responsible for cancer
related deaths, the mechanisms governing the process remain poorly defined. Moreover, …

BRN 2, a POU erful driver of melanoma phenotype switching and metastasis

ME Fane, Y Chhabra, AG Smith… - Pigment Cell & …, 2019 - Wiley Online Library
The POU domain family of transcription factors play a central role in embryogenesis and are
highly expressed in neural crest cells and the developing brain. BRN 2 is a class III POU …

[HTML][HTML] A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Y Chhabra, HY Wong, LF Nikolajsen, H Steinocher… - Oncogene, 2018 - nature.com
Both humans and mice lacking functional growth hormone (GH) receptors are known to be
resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. …

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

…, E Rumi, D Pietra, S Wilcox, Y Chhabra… - Blood, The Journal …, 2020 - ashpublications.org
… Error bars indicate the standard deviations of enrichment scores calculated in Enrich2 (y-axis)
and standard deviation of final cell counts in the experiment from panel (B) (x-axis). ns, not …

Deployment of distributed clustering approach in WSNs and IoTs

P Bhambri, Y Chhabra - Cloud and Fog Computing Platforms for …, 2022 - taylorfrancis.com
Wireless Sensor Networks are very useful technologies used in every department such as
military, health departments, education departments, agricultural departments, industrial …