User profiles for Y. Doyon

Yannick Doyon

Full Professor, Université Laval, Quebec, Canada
Verified email at crchudequebec.ulaval.ca
Cited by 9927

The highly conserved and multifunctional NuA4 HAT complex

Y Doyon, J Côté - Current opinion in genetics & development, 2004 - Elsevier
Histone acetyltransferase complexes have been shown to be key regulators of gene expression.
Among these, the NuA4 complex, first characterized in yeast, stands out as it controls …

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

VK Shukla, Y Doyon, JC Miller, RC DeKelver… - Nature, 2009 - nature.com
… X-axis labels indicate transgenic event number; y-axis indicates levels of IPK1 mRNA … X-axis
labels indicate groupings of samples according to detection of PAT mRNA; y-axis indicates …

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Y Doyon, JM McCammon, JC Miller, F Faraji… - Nature …, 2008 - nature.com
We describe the use of zinc-finger nucleases (ZFNs) for somatic and germline disruption of
genes in zebrafish (Danio rerio), in which targeted mutagenesis was previously intractable. …

In vivo genome editing restores haemostasis in a mouse model of haemophilia

H Li, V Haurigot, Y Doyon, T Li, SY Wong, AS Bhagwat… - Nature, 2011 - nature.com
Editing of the human genome to correct disease-causing mutations is a promising approach
for the treatment of genetic disorders. Genome editing improves on simple gene-…

[PDF][PDF] ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

Y Doyon, C Cayrou, M Ullah, AJ Landry, V Côté… - Molecular cell, 2006 - cell.com
Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis,
and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the …

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

Y Doyon, W Selleck, WS Lane, S Tan… - Molecular and cellular …, 2004 - Am Soc Microbiol
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation
of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is essential …

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

Y Doyon, TD Vo, MC Mendel, SG Greenberg, J Wang… - Nature …, 2011 - nature.com
Zinc-finger nucleases (ZFNs) drive efficient genome editing by introducing a double-strand
break into the targeted gene. Cleavage is induced when two custom-designed ZFNs …

Targeted transgene integration in plant cells using designed zinc finger nucleases

CQ Cai, Y Doyon, WM Ainley, JC Miller… - Plant molecular …, 2009 - Springer
Targeted transgene integration in plants remains a significant technical challenge for both
basic and applied research. Here it is reported that designed zinc finger nucleases (ZFNs) can …

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells

…, JM Cherone, Y Santiago, AH Lee, TD Vo, Y Doyon… - Nature cell …, 2011 - nature.com
Clathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively
internalize molecules from the plasma membrane and surrounding environment. Previous …

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

R Sharma, XM Anguela, Y Doyon… - Blood, The Journal …, 2015 - ashpublications.org
Site-specific genome editing provides a promising approach for achieving long-term, stable
therapeutic gene expression. Genome editing has been successfully applied in a variety of …