User profiles for Y. Doyon
Yannick DoyonFull Professor, Université Laval, Quebec, Canada Verified email at crchudequebec.ulaval.ca Cited by 9927 |
The highly conserved and multifunctional NuA4 HAT complex
Histone acetyltransferase complexes have been shown to be key regulators of gene expression.
Among these, the NuA4 complex, first characterized in yeast, stands out as it controls …
Among these, the NuA4 complex, first characterized in yeast, stands out as it controls …
Precise genome modification in the crop species Zea mays using zinc-finger nucleases
… X-axis labels indicate transgenic event number; y-axis indicates levels of IPK1 mRNA … X-axis
labels indicate groupings of samples according to detection of PAT mRNA; y-axis indicates …
labels indicate groupings of samples according to detection of PAT mRNA; y-axis indicates …
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases
We describe the use of zinc-finger nucleases (ZFNs) for somatic and germline disruption of
genes in zebrafish (Danio rerio), in which targeted mutagenesis was previously intractable. …
genes in zebrafish (Danio rerio), in which targeted mutagenesis was previously intractable. …
In vivo genome editing restores haemostasis in a mouse model of haemophilia
Editing of the human genome to correct disease-causing mutations is a promising approach
for the treatment of genetic disorders. Genome editing improves on simple gene-…
for the treatment of genetic disorders. Genome editing improves on simple gene-…
[PDF][PDF] ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation
Y Doyon, C Cayrou, M Ullah, AJ Landry, V Côté… - Molecular cell, 2006 - cell.com
Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis,
and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the …
and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the …
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation
of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is essential …
of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is essential …
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
Zinc-finger nucleases (ZFNs) drive efficient genome editing by introducing a double-strand
break into the targeted gene. Cleavage is induced when two custom-designed ZFNs …
break into the targeted gene. Cleavage is induced when two custom-designed ZFNs …
Targeted transgene integration in plant cells using designed zinc finger nucleases
Targeted transgene integration in plants remains a significant technical challenge for both
basic and applied research. Here it is reported that designed zinc finger nucleases (ZFNs) can …
basic and applied research. Here it is reported that designed zinc finger nucleases (ZFNs) can …
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells
Clathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively
internalize molecules from the plasma membrane and surrounding environment. Previous …
internalize molecules from the plasma membrane and surrounding environment. Previous …
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
R Sharma, XM Anguela, Y Doyon… - Blood, The Journal …, 2015 - ashpublications.org
Site-specific genome editing provides a promising approach for achieving long-term, stable
therapeutic gene expression. Genome editing has been successfully applied in a variety of …
therapeutic gene expression. Genome editing has been successfully applied in a variety of …