Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate
corepressor proteins into specific transcriptional repression complexes that target HDAC activity to …

In order to survive, bacteria continually sense, and respond to, environmental fluctuations.
Stringent control represents a key bacterial stress response to nutrient starvation 1 , 2 that …

The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription
raises questions as to whether the translation machinery and prokaryotic proteins are …

A key step in translational initiation is the recruitment of the 43S preinitiation complex by the
cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5′ end of messenger …

Newly transcribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at
their 3′ ends by the ~1-megadalton multiprotein cleavage and polyadenylation factor (CPF). …

One of the responses to stress by eukaryotic cells is the down-regulation of protein synthesis
by phosphorylation of translation initiation factor eIF2. Phosphorylation results in low …

10.7554/eLife.39273.001 In eukaryotic translation initiation, AUG recognition of the mRNA
requires accommodation of Met-tRNA i in a ‘P IN ’ state, which is antagonized by the factor …

eIF2B facilitates and controls protein synthesis in eukaryotes by mediating guanine nucleotide
exchange on its partner eIF2. We combined mass spectrometry (MS) with chemical cross-…

… We thank Y. Shimizu for providing the arfA clone, AC Kelley for providing tRNA, RS Hegde …
We thank Y. Shimizu for providing the arfA clone, AC Kelley for providing tRNA, RS Hegde for …

Eukaryotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2
and a critical regulator of protein synthesis, (eg., as part of the integrated stress response). …