A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …

MYOGENIN is a member of the basic helix-loop-helix (bHLH) gene family and converts
multipotential mesodermal cells to myoblasts 1–4 . The four members of the myoD family show …

To escape aging and aging-related disorders has been one of mankind’s biggest dreams
from the beginning of history. However, our knowledge regarding the molecular mechanisms …

We found adult human stem cells that can generate, from a single cell, cells with the
characteristics of the three germ layers. The cells are stress-tolerant and can be isolated from …

Inactivation of theklotho(kl) gene in mice results in multiple disorders that resemble human
aging. The mouseklgene encodes a novel single-pass membrane protein with homology to β-…

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a
method for inducing skeletal muscle lineage cells from human and rat general adherent …

Sonic hedgehog (Shh), an organizing signal from ventral midline structures, is essential for
the induction and maintenance of many ventral cell types in the embryonic neural tube. Olig1 …

Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the
function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral …

α-klotho was identified as a gene associated with premature aging–like phenotypes
characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and …