Stability: recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team

N van de Merbel, N Savoie, M Yadav, Y Ohtsu… - The AAPS Journal, 2014 - Springer
This paper provides a comprehensive overview of stability-related aspects of quantitative
bioanalysis and recommends science-based best practices, covering small and large …

[HTML][HTML] Sweet taste-sensing receptors expressed in pancreatic β-cells: sweet molecules act as biased agonists

I Kojima, Y Nakagawa, Y Ohtsu, A Medina… - Endocrinology and …, 2014 - ncbi.nlm.nih.gov
The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2
and T1R3. This receptor is also expressed in pancreatic β-cells. When the expression of …

[HTML][HTML] Pharmacokinetic drug interaction studies with enzalutamide

JA Gibbons, M de Vries, W Krauwinkel, Y Ohtsu… - Clinical …, 2015 - Springer
Background and Objectives Two phase I drug interaction studies were performed with oral
enzalutamide, which is approved for the treatment of metastatic castration-resistant prostate …

[HTML][HTML] CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

…, T Takeuchi, N Ohshima, T Furuki, Y Ohtsu… - Nature …, 2020 - nature.com
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells
are destroyed. Intestinal helminths can cause asymptomatic chronic and …

[HTML][HTML] Clinical pharmacokinetic studies of enzalutamide

JA Gibbons, T Ouatas, W Krauwinkel, Y Ohtsu… - Clinical …, 2015 - Springer
Background and Objectives Oral enzalutamide (160 mg once daily) is approved for the
treatment of metastatic castration-resistant prostate cancer (mCRPC). This article describes the …

Return of the glucoreceptor: Glucose activates the glucose‐sensing receptor T1R3 and facilitates metabolism in pancreatic β‐cells

I Kojima, Y Nakagawa, Y Ohtsu… - Journal of diabetes …, 2015 - Wiley Online Library
Subunits of the sweet taste receptor, namely T1R2 and T1R3, are expressed in mouse
pancreatic islets. Quantitatively, the expression of messenger ribonucleic acid for T1R2 is much …

Fine mapping of the subunit binding sites of influenza virus RNA polymerase

Y Ohtsu, Y Honda, Y Sakata, H Kato… - Microbiology and …, 2002 - Wiley Online Library
Influenza virus RNA polymerase consists of three subunits, PB1, PB2 and PA, and catalyzes
both transcription and replication of the RNA genome. PB1 is a catalytic subunit of RNA …

A fatal poisoning case by intravenous injection of “bath salts” containing acetyl fentanyl and 4-methoxy PV8

…, A Sasao, S Mishima, Y Ohtsu, Y Nishitani - Forensic science …, 2016 - Elsevier
A man in his 30’s was found at home, not breathing. He was admitted to an emergency
hospital and the doctor confirmed his death. He had a history of methamphetamine abuse …

Magnetization and torque measurements on Nd2Fe14B single crystals

K Tokuhara, Y Ohtsu, F Ono, O Yamada… - Solid state …, 1985 - Elsevier
Magnetization and torque measurements on single crystal specimens of Nd 2 Fe 14 B have
been carried out. The magnetization values measured always in the direction of easy …

Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells

Y Ohtsu, Y Nakagawa, M Nagasawa, S Takeda… - Molecular and Cellular …, 2014 - Elsevier
Sweet taste receptor regulates GLP-1 secretion in enteroendocrine L-cells. We investigated
the signaling system activated by this receptor using Hutu-80 cells. We stimulated them with …