The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia.
However, strategies to target this TF have yet to be identified. Here, we used a domain-focused …

Targeting of general coactivators is an emerging strategy to interfere with oncogenic
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects by …

… The x axis shows genomic position and y axis shows signal of ChIP-seq occupancy in
units of reads per million mapped reads. (H) Ranking of ZFP64 binding intensity at highconfidence …

… where Y ab,O is the observed percentage inhibition of combined drug A and B; Y ab,P is
the … A and B; Y a is the percentage inhibition by drug A at dose a; and Y b is the percentage …

Dysregulated gene expression contributes to most prevalent features in human cancers.
Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant …

In fission yeast, the DNA damage sensor kinases Tel1 ATM and Rad3 ATR exist at telomeres
and are required for telomere maintenance, but the biological role they play at telomeres is …

Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA
to lysine residues of histones and play a central role in transcriptional regulation in diverse …

… When we probed neutral-neutral 2D gels for subtelomere regions, we found no Y-arc-shaped
replication intermediates in cycling cells. We conclude that the loss of telomere and …

Acute leukemia cells require bone marrow microenvironments, known as niches, which
provide leukemic cells with niche factors that are essential for leukemic cell survival and/or …

Modern sugarcane cultivars are highly polyploid and have giant genomes (10 giga bases (Gb))
derived from interspecific hybridization between the cultivated species S. officinarum L. …